HMM Summary Page: TIGR00236

FunctionUDP-N-acetylglucosamine 2-epimerase
Trusted Cutoff210.15
Domain Trusted Cutoff210.15
Noise Cutoff69.95
Domain Noise Cutoff69.95
Isology Typeequivalog
EC Number5.1.3.14
HMM Length366
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0008761: UDP-N-acetylglucosamine 2-epimerase activity molecular_function
GO:0009103: lipopolysaccharide biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis cytosolic enzyme converts UDP-N-acetyl-D-glucosamine to UDP-N-acetyl-D-mannosamine. In E. coli, this is the first step in the pathway of enterobacterial common antigen biosynthesis. Members of this orthology group have many gene symbols, often reflecting the overall activity of the pathway and/or operon that includes it. Symbols include epsC (exopolysaccharide C) in Burkholderia solanacerum, cap8P (type 8 capsule P) in Staphylococcus aureus, and nfrC in an older designation based on the effects of deletion on phage N4 adsorption. Epimerase activity was also demonstrated in a bifunctional rat enzyme, for which the N-terminal domain appears to be orthologous. The set of proteins found above the suggested cutoff includes E. coli WecB in one of two deeply branched clusters and the rat UDP-N-acetylglucosamine 2-epimerase domain in the other.
ReferencesA2 hmmalign DR ECOCYC; EG11451; wecB SE TIGR GA hmmls AL clustalw, belvu, seaview BD 0328
Genome PropertyGenProp0912: Leptospira exopolysaccharide biosynthesis clusters (HMM-CLUST)
GenProp0975: biosynthesis of UDP-N-acetyl-D-mannosamine (UDP-ManNAc) (HMM)