| Accession | TIGR00229 |
| Name | sensory_box |
| Function | PAS domain S-box protein |
| Trusted Cutoff | 22.90 |
| Domain Trusted Cutoff | 22.90 |
| Noise Cutoff | 22.10 |
| Domain Noise Cutoff | 22.10 |
| Isology Type | domain |
| HMM Length | 126 |
| Mainrole Category | Regulatory functions |
| Subrole Category | Small molecule interactions |
| Gene Ontology Term | GO:0004871: signal transducer activity molecular_function |
| | GO:0007165: signal transduction biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:09PM |
| Last Modified | Jul 18 2011 3:04PM |
| Comment | The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. |
| References | A2 hmmalign
RL Trends Biochem Sci 1997 Sep;22(9):331-333;
RM 97446881;
RA Zhulin IB, Taylor BL, Dixon R;
RT PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox.
SE TIGR
GA hmmls
AL clustalw
BD 0296 |
