HMM Summary Page: TIGR00220

Functionlarge conductance mechanosensitive channel protein
Gene SymbolmscL
Trusted Cutoff71.00
Domain Trusted Cutoff71.00
Noise Cutoff43.30
Domain Noise Cutoff43.30
Isology Typeequivalog
HMM Length127
Mainrole CategoryCellular processes
Subrole CategoryAdaptations to atypical conditions
Gene Ontology TermGO:0006810: transport biological_process
GO:0022833: mechanically gated channel activity molecular_function
AuthorLoftus BJ
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentProtein encodes a channel which opens in response to a membrane stretch force. Probably serves as an osmotic gauge. Carboxy terminus tends to be more divergent across species with a high degree of sequence conservation found at the N-terminus.
ReferencesDR ECOCYC; EG11180; mscL; SE TIGR GA hmmls AL clustalw RM 97045088 DR HAMAP; MF_00115; 260 of 262