HMM Summary Page: TIGR00218

Functionmannose-6-phosphate isomerase, class I
Gene SymbolmanA
Trusted Cutoff116.20
Domain Trusted Cutoff116.20
Noise Cutoff59.15
Domain Noise Cutoff59.15
Isology Typeequivalog
EC Number5.3.1.8
HMM Length359
Mainrole CategoryEnergy metabolism
Subrole CategorySugars
Gene Ontology TermGO:0004476: mannose-6-phosphate isomerase activity molecular_function
GO:0005975: carbohydrate metabolic process biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe names phosphomannose isomerase and mannose-6-phosphate isomerase are synonomous. This family contains two rather deeply branched groups. One group contains an experimentally determined phosphomannose isomerase of Streptococcus mutans as well as three uncharacterized paralogous proteins of Bacillus subtilis, all at more than 50 % identity to each other, plus a more distant homolog from Archaeoglobus fulgidus. The other group contains members from E. coli, budding yeast, Borrelia burgdorferi, etc.
ReferencesA2 hmmalign SE TIGR GA hmmls AL clustalw, belvu BD 0269 DR PROSITE; PDOC00746; DR PFAM; PF01238; PMI_typeI