HMM Summary Page: TIGR00216

Function4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Gene SymbolispH
Trusted Cutoff187.85
Domain Trusted Cutoff187.85
Noise Cutoff103.60
Domain Noise Cutoff103.60
Isology Typeequivalog
EC Number1.17.1.2
HMM Length282
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0009240: isopentenyl diphosphate biosynthetic process biological_process
GO:0015968: stringent response biological_process
GO:0046677: response to antibiotic biological_process
GO:0051745: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity molecular_function
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe IspH protein (previously designated LytB) has now been recognized as the last enzyme in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Escherichia coli LytB protein had been found to regulate the activity of RelA (guanosine 3',5'-bispyrophosphate synthetase I), which in turn controls the level of a regulatory metabolite. It is involved in penicillin tolerance and the stringent response.
ReferencesRN [1] RM PMID: 11818558 RT Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein. RA Rohdich F, Hecht S, Gartner K, Adam P, Krieger C, Amslinger S, Arigoni D, Bacher A, Eisenreich W. RL Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1158-63. DR ECOCYC; EG11081; lytB; DR PFAM; PF02401; LYTB DR InterPro; IPR003451; LytB SE TIGR GA hmmls RM 98196746 RM 98079441 DR HAMAP; MF_00191; 291 of 300
Genome PropertyGenProp0048: IPP biosynthesis via deoxyxylulose (HMM)