HMM Summary Page: TIGR00214

Functionlipoyl(octanoyl) transferase
Gene SymbollipB
Trusted Cutoff83.55
Domain Trusted Cutoff83.55
Noise Cutoff64.65
Domain Noise Cutoff64.65
Isology Typeequivalog
EC Number2.3.1.181
HMM Length187
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0009107: lipoate biosynthetic process biological_process
GO:0016979: lipoate-protein ligase activity molecular_function
AuthorLoftus BJ
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentInvolved in lipoate biosynthesis as the main determinant of the lipoyl-protein ligase activity required for lipoylation of enzymes such as alpha-ketoacid dehydrogenases. Involved in activation and re-activation (following denaturation) of lipoyl-protein ligases (calcium ion-dependant process).
ReferencesDR ECOCYC; EG11591; DR PROSITE; PDOC01017; SE TIGR AL clustalw RN [1] RM 12591875 RT The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase. RA Jordan SW, Cronan JE Jr. DR HAMAP; MF_00013; 331 of 337
Genome PropertyGenProp0745: lipoyl-protein attachment (HMM)