HMM Summary Page: TIGR00211

Functionglycine--tRNA ligase, beta subunit
Gene SymbolglyS
Trusted Cutoff321.95
Domain Trusted Cutoff321.95
Noise Cutoff296.90
Domain Noise Cutoff296.90
Isology Typeequivalog_domain
EC Number6.1.1.14
HMM Length691
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004820: glycine-tRNA ligase activity molecular_function
GO:0006426: glycyl-tRNA aminoacylation biological_process
GO:0009345: glycine-tRNA ligase complex cellular_component
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe glycyl-tRNA synthetases differ even among the eubacteria in oligomeric structure. In Escherichia coli and most others, it is a heterodimer of two alpha chains and two beta chains, encoded by tandem genes. The genes are similar, but fused, in Chlamydia trachomatis. By contrast, the glycyl-tRNA synthetases of Thermus thermophilus and of archaea and eukaryotes differ considerably; they are homodimeric, mutually similar, and not detected by this model.
ReferencesRM 98149692 RT Glycyl-tRNA synthetase from Thermus thermophilus--wide structural divergence with other prokaryotic glycyl-tRNA synthetases and functional inter-relation with prokaryotic and eukaryotic glycylation systems. RA Mazauric MH, Keith G, Logan D, Kreutzer R, Giege R, Kern D. RL Eur J Biochem. 1998 Feb 1;251(3):744-57. SE TIGR DR HAMAP; MF_00255; 151 of 157
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)