| Accession | TIGR00204 |
| Name | dxs |
| Function | 1-deoxy-D-xylulose-5-phosphate synthase |
| Gene Symbol | dxs |
| Trusted Cutoff | 465.95 |
| Domain Trusted Cutoff | 465.95 |
| Noise Cutoff | 222.45 |
| Domain Noise Cutoff | 222.45 |
| Isology Type | equivalog |
| EC Number | 2.2.1.7 |
| HMM Length | 616 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0008615: pyridoxine biosynthetic process biological_process |
| | GO:0008661: 1-deoxy-D-xylulose-5-phosphate synthase activity molecular_function |
| | GO:0009228: thiamine biosynthetic process biological_process |
| | GO:0009240: isopentenyl diphosphate biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:07PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | DXP synthase is a thiamine diphosphate-dependent enzyme related to transketolase and the pyruvate dehydrogenase E1-beta subunit. By an acyloin condensation of pyruvate with glyceraldehyde 3-phosphate, it produces 1-deoxy-D-xylulose 5-phosphate, a precursor of thiamine diphosphate (TPP), pyridoxal phosphate, and the isoprenoid building block isopentenyl diphosphate (IPP). |
| References | DR PROSITE; PDOC00635
RM 98151473
RT Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.
RA Lois LM, Campos N, Putra SR, Danielsen K, Rohmer M, Boronat A
RL Proc Natl Acad Sci U S A 1998 Mar 3;95(5):2105-10
SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_00315; 373 of 379 |
| Genome Property | GenProp0048: IPP biosynthesis via deoxyxylulose (HMM) |
