HMM Summary Page: TIGR00183

Functionisocitrate dehydrogenase, NADP-dependent
Gene Symbolicd
Trusted Cutoff567.30
Domain Trusted Cutoff567.30
Noise Cutoff219.05
Domain Noise Cutoff219.05
Isology Typeequivalog
EC Number1.1.1.42
HMM Length417
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0004450: isocitrate dehydrogenase (NADP+) activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentSeveral NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases.
ReferencesA2 hmmalign SE TIGR GA hmmls AL clustalw, belvu BD build_dir/0253
Genome PropertyGenProp0033: TCA cycle (HMM)