Accession | TIGR00183 |
Name | prok_nadp_idh |
Function | isocitrate dehydrogenase, NADP-dependent |
Gene Symbol | icd |
Trusted Cutoff | 567.30 |
Domain Trusted Cutoff | 567.30 |
Noise Cutoff | 219.05 |
Domain Noise Cutoff | 219.05 |
Isology Type | equivalog |
EC Number | 1.1.1.42 |
HMM Length | 417 |
Mainrole Category | Energy metabolism |
Subrole Category | TCA cycle |
Gene Ontology Term | GO:0004450: isocitrate dehydrogenase (NADP+) activity molecular_function |
| GO:0006099: tricarboxylic acid cycle biological_process |
Author | Haft DH |
Entry Date | Apr 20 1999 2:09PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site;
Prokaryotic NADP-dependent isocitrate dehydrogenases resemble their NAD-dependent counterparts and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent isocitrate dehydrogenases. |
References | A2 hmmalign
SE TIGR
GA hmmls
AL clustalw, belvu
BD build_dir/0253 |
Genome Property | GenProp0033: TCA cycle (HMM) |