HMM Summary Page: TIGR00180

FunctionParB/RepB/Spo0J family partition protein
Trusted Cutoff58.45
Domain Trusted Cutoff58.45
Noise Cutoff39.80
Domain Noise Cutoff39.80
Isology Typedomain
HMM Length186
Gene Ontology TermGO:0000910: cytokinesis biological_process
GO:0003677: DNA binding molecular_function
GO:0007059: chromosome segregation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 21 2012 12:32PM
CommentThis HMM represents the most well-conserved core of a set of chromosomal and plasmid partition proteins related to ParB, including Spo0J, RepB, and SopB. Spo0J has been shown to bind a specific DNA sequence that, when introduced into a plasmid, can serve as partition site. Study of RepB, which has nicking-closing activity, suggests that it forms a transient protein-DNA covalent intermediate during the strand transfer reaction.
ReferencesRL J Mol Biol 1997 May 23;268(5):840-856. RM 97324207; RL Cell 1998 Mar 6;92(5):675-685, RM 98165347 SE TIGR DR HAMAP; MF_02015; 22 of 22