HMM Summary Page: TIGR00173

Function2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
Gene SymbolmenD
Trusted Cutoff244.20
Domain Trusted Cutoff244.20
Noise Cutoff183.05
Domain Noise Cutoff183.05
Isology Typeequivalog
EC Number2.2.1.9
HMM Length435
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0009234: menaquinone biosynthetic process biological_process
GO:0070204: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentMenD was thought until recently to act as SHCHC synthase, but has recently been shown to act instead as SEPHCHC synthase. Conversion of SEPHCHC into SHCHC and pyruvate may occur spontaneously but is catalyzed efficiently, at least in some organisms, by MenH (see TIGR03695). 2-oxoglutarate decarboxylase/SHCHC synthase (menD) is a thiamine pyrophosphate enzyme involved in menaquinone biosynthesis.
ReferencesRN [1] RM PMID:17760421 RT Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity. RA Jiang M, Cao Y, Guo ZF, Chen M, Chen X, Guo Z RL Biochemistry. 2007 Sep 25;46(38):10979-89. Epub 2007 Aug 31. DR HAMAP; MF_01659; 164 of 212
Genome PropertyGenProp0058: menaquinone biosynthesis via SEPHCHC (HMM)