HMM Summary Page: TIGR00171

Function3-isopropylmalate dehydratase, small subunit
Gene SymbolleuD
Trusted Cutoff116.25
Domain Trusted Cutoff116.25
Noise Cutoff81.90
Domain Noise Cutoff81.90
Isology Typeequivalog_domain
EC Number4.2.1.33
HMM Length188
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0003861: 3-isopropylmalate dehydratase activity molecular_function
GO:0009098: leucine biosynthetic process biological_process
GO:0009316: 3-isopropylmalate dehydratase complex cellular_component
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentHomoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures. All are dehydratases (EC 4.2.1.-) and bind a Fe-4S iron-sulfur cluster. 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble the leuC and leuD pair in length and sequence but even more closely resemble the respective domains of homoaconitase, and their identity is uncertain. The candidate archaeal leuD proteins are not included in the seed alignment for this model and score below the trusted cutoff.
ReferencesDR PROSITE; PDOC00423; SE TIGR GA hmmls AL clustalw DR HAMAP; MF_01031; 321 of 330
Genome PropertyGenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)