HMM Summary Page: TIGR00170

Function3-isopropylmalate dehydratase, large subunit
Gene SymbolleuC
Trusted Cutoff560.25
Domain Trusted Cutoff560.25
Noise Cutoff226.80
Domain Noise Cutoff226.80
Isology Typeequivalog_domain
EC Number4.2.1.33
HMM Length466
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0003861: 3-isopropylmalate dehydratase activity molecular_function
GO:0009098: leucine biosynthetic process biological_process
GO:0009316: 3-isopropylmalate dehydratase complex cellular_component
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are 3-isopropylmalate dehydratase, large subunit, or the large subunit domain of single-chain forms. Homoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures. All are dehydratases (EC 4.2.1.-) and bind a Fe-4S iron-sulfur cluster. 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble the leuC and leuD pair in length and sequence but even more closely resemble the respective domains of homoaconitase, and their identity is uncertain. These homologs are now described by a separate model of subfamily (rather than equivalog) homology type, and the priors and cutoffs for this model have been changed to focus this equivalog family more narrowly.
ReferencesDR PROSITE; PDOC00423; DR HAMAP; MF_01026; 355 of 360
Genome PropertyGenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)