HMM Summary Page: TIGR00164

Functionphosphatidylserine decarboxylase homolog
Trusted Cutoff144.75
Domain Trusted Cutoff144.75
Noise Cutoff56.85
Domain Noise Cutoff56.85
Isology Typehypoth_equivalog
HMM Length215
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentPhosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. This protein has many regions of homology to known phosphatidylserine decarboxylases, including the Gly-Ser motif for chain cleavage and active site generation, but has a shorter amino end and a number of deletions along the length of the alignment to the phosphatidylserine decarboxylases. It is unclear whether this protein is a form of phosphatidylserine decarboxylase or is a related enzyme. It is found in Neisseria gonorrhoeae, Mycobacterium tuberculosis, and several archaeal species, all of which lack known phosphatidylserine decarboxylase.
ReferencesSE TIGR AL clustalw DR HAMAP; MF_00664; 152 of 153