HMM Summary Page: TIGR00157

Functionribosome small subunit-dependent GTPase A
Gene SymbolrsgA
Trusted Cutoff100.00
Domain Trusted Cutoff100.00
Noise Cutoff60.00
Domain Noise Cutoff60.00
Isology Typeequivalog
EC Number3.6.-.-
HMM Length247
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0005525: GTP binding molecular_function
GO:0006412: translation biological_process
GO:0043022: ribosome binding molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option).
ReferencesRN [1] RM 12220175 RT YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics. RA Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED. RL Biochemistry 2002 Sep 17;41(37):11109-17 RN [2] RM 14973029 RT Studies of the interaction of Escherichia coli YjeQ with the ribosome in vitro. RA Daigle DM, Brown ED. RL J Bacteriol. 2004 Mar;186(5):1381-7. RN [3] RM 15466596 RT A novel GTPase activated by the small subunit of ribosome. RA Himeno H, Hanawa-Suetsugu K, Kimura T, Takagi K, Sugiyama W, Shirata S, Mikami T, Odagiri F, Osanai Y, Watanabe D, Goto S, Kalachnyuk L, Ushida C, Muto A. RL Nucleic Acids Res. 2004 Oct 05;32(17):5303-9. DR HAMAP; MF_01820; 94 of 102
Genome PropertyGenProp0802: ribosome biogenesis proteins, bacteria (HMM)