HMM Summary Page: TIGR00154

Function4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
Gene SymbolispE
Trusted Cutoff138.70
Domain Trusted Cutoff138.70
Noise Cutoff105.20
Domain Noise Cutoff105.20
Isology Typeequivalog
EC Number2.7.1.148
HMM Length294
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0016114: terpenoid biosynthetic process biological_process
GO:0050515: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis.
ReferencesDR SWISS-PROT; P24209; annotated E. coli entry DR PROSITE; PDOC0054; DR ECOCYC; EG11294; ispE RN [1] RT Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. RA Luttgen H, Rohdich F, Herz S, Wungsintaweekul J, Hecht S, Schuhr CA, Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W. RL Proc Natl Acad Sci U S A 2000 Feb 1;97(3):1062-7 RM 10655484 RN [2] RM 97201482 SE TIGR DR HAMAP; MF_00061; 411 of 432
Genome PropertyGenProp0048: IPP biosynthesis via deoxyxylulose (HMM)