| Accession | TIGR00154 |
| Name | ispE |
| Function | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase |
| Gene Symbol | ispE |
| Trusted Cutoff | 138.70 |
| Domain Trusted Cutoff | 138.70 |
| Noise Cutoff | 105.20 |
| Domain Noise Cutoff | 105.20 |
| Isology Type | equivalog |
| EC Number | 2.7.1.148 |
| HMM Length | 294 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0016114: terpenoid biosynthetic process biological_process |
| | GO:0050515: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity molecular_function |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:05PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. |
| References | DR SWISS-PROT; P24209; annotated E. coli entry
DR PROSITE; PDOC0054;
DR ECOCYC; EG11294; ispE
RN [1]
RT Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
RA Luttgen H, Rohdich F, Herz S, Wungsintaweekul J, Hecht S, Schuhr CA, Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W.
RL Proc Natl Acad Sci U S A 2000 Feb 1;97(3):1062-7
RM 10655484
RN [2]
RM 97201482
SE TIGR
DR HAMAP; MF_00061; 411 of 432 |
| Genome Property | GenProp0048: IPP biosynthesis via deoxyxylulose (HMM) |
