HMM Summary Page: TIGR00149

Functionsecondary thiamine-phosphate synthase enzyme
Trusted Cutoff67.75
Domain Trusted Cutoff67.75
Noise Cutoff48.95
Domain Noise Cutoff48.95
Isology Typehypoth_equivalog
HMM Length132
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0008150: biological_process biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family have been studied extensively by crystallography. Members from several different species have been shown to have sufficient thiamin phosphate synthase activity (EC to complement thiE mutants. However, it is presumed that this is a secondary activity, and the primary function of this enzyme remains unknown.
ReferencesRN [1] RM PMID:18178222 RT Sensitive genome-wide screen for low secondary enzymatic activities: the YjbQ family shows thiamin phosphate synthase activity. RA Morett E, Saab-Rincon G, Olvera L, Olvera M, Flores H, Grande R RL J Mol Biol. 2008 Feb 22;376(3):839-53. Epub 2007 Dec 15.