HMM Summary Page: TIGR00144

Functionbeta-ribofuranosylaminobenzene 5'-phosphate synthase family
Trusted Cutoff113.50
Domain Trusted Cutoff113.50
Noise Cutoff44.70
Domain Noise Cutoff44.70
Isology Typesubfamily
HMM Length325
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
AuthorHaft DH
Entry DateApr 20 1999 2:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family contains several archaeal examples of beta-ribofuranosylaminobenzene 5-prime-phosphate synthase (beta-RFAP synthase), an enzyme involved in methanopterin biosynthesis. In some species, two members of this family are found. It is unclear whether both act as beta-RFAP synthase. This family is related to the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase). Members are found so far only in the Archaea and in Methylobacterium extorquens.
ReferencesDR PROSITE; PDOC00545; RN [1] RM 12142414 RT Purification, overproduction, and partial characterization of beta-RFAP synthase, a key enzyme in the methanopterin biosynthesis pathway. RA Scott JW, Rasche ME. RL J Bacteriol. 2002 Aug;184(16):4442-8.