HMM Summary Page: TIGR00139

Gene SymbollysF
Trusted Cutoff529.90
Domain Trusted Cutoff529.90
Noise Cutoff315.30
Domain Noise Cutoff315.30
Isology Typeequivalog
EC Number4.2.1.36
HMM Length709
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0004409: homoaconitate hydratase activity molecular_function
GO:0009085: lysine biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentHomoaconitase is known only as a fungal enzyme from two species, where it is part of an unusual lysine biosynthesis pathway. Because this HMM is based on just two sequences from a narrow taxonomic range, it may not recognize distant orthologs, should any exist. Homoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures, but 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble leuC and leuD over their lengths but are even closer to the respective domains of homoaconitase, and their identity is uncertain.
ReferencesA2 hmmalign RL Microbiology 1996 Feb;142( Pt 2):389-400 SE TIGR GA hmmls AL clustalw BD build_dir/0250