HMM Summary Page: TIGR00136

FunctiontRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA
Gene SymbolgidA
Trusted Cutoff524.85
Domain Trusted Cutoff524.85
Noise Cutoff97.00
Domain Noise Cutoff97.00
Isology Typeequivalog
HMM Length616
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0006400: tRNA modification biological_process
GO:0016740: transferase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentGidA, the longer of two forms of GidA-related proteins, appears to be present in all complete eubacterial genomes so far, as well as Saccharomyces cerevisiae. A subset of these organisms have a closely related protein. GidA is absent in the Archaea. It appears to act with MnmE, in an alpha2/beta2 heterotetramer, in the 5-carboxymethylaminomethyl modification of uridine 34 in certain tRNAs. The shorter, related protein, previously called gid or gidA(S), is now called TrmFO (see model TIGR00137).
ReferencesRN [1] RM PMID: 17062623 RT Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli. RA Yim L, Moukadiri I, Bjork GR, Armengod ME RL Nucleic Acids Res. 2006;34(20):5892-905. DR HAMAP; MF_00129; 524 of 540
Genome PropertyGenProp0704: tRNA U34 carboxymethylaminomethyl modification (HMM)