HMM Summary Page: TIGR00135

Functionaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit
Gene SymbolgatC
Trusted Cutoff47.10
Domain Trusted Cutoff47.10
Noise Cutoff29.35
Domain Noise Cutoff29.35
Isology Typeequivalog
EC Number6.3.5.-
HMM Length93
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0006424: glutamyl-tRNA aminoacylation biological_process
GO:0030956: glutamyl-tRNA(Gln) amidotransferase complex cellular_component
GO:0050567: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentArchaea, organelles, and many bacteria charge Gln-tRNA by first misacylating it with Glu and then amidating Glu to Gln. This small protein is part of the amidotransferase heterotrimer and appears to be important to the stability of the amidase subunit encode by gatA, but its function may not be required in every organism that expresses gatA and gatB. The seed alignment for this HMM does not include any eukaryotic sequence and is not guaranteed to find eukaryotic examples, although it does find some. Saccharomyces cerevisiae, which expresses the amidotransferase for mitochondrial protein translation, seems to lack a gatC ortholog. This HMM has been revised to remove the candidate sequence from Methanococcus jannaschii, now part of a related model.
ReferencesDR Proc Natl Acad Sci USA 94, 11819-11826, 1997 SE TIGR AL clustalw, belvu, seaview DR HAMAP; MF_00122; 324 of 325
Genome PropertyGenProp0188: GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex (HMM)
GenProp0258: tRNA aminoacylation (HMM)
GenProp0258: tRNA aminoacylation (HMM)