HMM Summary Page: TIGR00131

Gene SymbolgalK
Trusted Cutoff226.65
Domain Trusted Cutoff226.65
Noise Cutoff185.00
Domain Noise Cutoff185.00
Isology Typeequivalog
EC Number2.7.1.6
HMM Length388
Mainrole CategoryEnergy metabolism
Subrole CategorySugars
Gene Ontology TermGO:0004335: galactokinase activity molecular_function
GO:0006012: galactose metabolic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentGalactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding. The galactokinases found by this HMM are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity.
ReferencesDR PROSITE; PDOC0054; SE TIGR GA hmmls AL clustalw, belvu, seaview DR HAMAP; MF_00246; 85 of 86
Genome PropertyGenProp0143: Leloir pathway (galactose/glucose interconversion) (HMM)