HMM Summary Page: TIGR00129

Functionformate dehydrogenase family accessory protein FdhD
Trusted Cutoff140.90
Domain Trusted Cutoff140.90
Noise Cutoff33.65
Domain Noise Cutoff33.65
Isology Typeequivalog
HMM Length237
Mainrole CategoryEnergy metabolism
Subrole CategoryAnaerobic
Gene Ontology TermGO:0008863: formate dehydrogenase (NAD+) activity molecular_function
GO:0009061: anaerobic respiration biological_process
GO:0009326: formate dehydrogenase complex cellular_component
GO:0015942: formate metabolic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentFdhD in E. coli and NarQ in B. subtilis are required for the activity of formate dehydrogenase. The gene name in B. subtilis reflects the requirement of the neighboring gene narA for nitrate assimilation, for which NarQ is not required. In some species, the gene is associated not with a known formate dehydrogenase but with a related putative molybdopterin-binding oxidoreductase. A reasonable hypothesis is that this protein helps prepare a required cofactor for assembly into the holoenzyme.
ReferencesGA hmmls AL clustalw, seaview DR HAMAP; MF_00187; 87 of 88