HMM Summary Page: TIGR00127

Functionisocitrate dehydrogenase, NADP-dependent
Trusted Cutoff397.15
Domain Trusted Cutoff397.15
Noise Cutoff103.45
Domain Noise Cutoff103.45
Isology Typeequivalog
EC Number1.1.1.42
HMM Length409
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0004450: isocitrate dehydrogenase (NADP+) activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide.
ReferencesSE TIGR GA hmmls
Genome PropertyGenProp0033: TCA cycle (HMM)