| Accession | TIGR00122 |
| Name | birA_repr_reg |
| Function | biotin operon repressor |
| Trusted Cutoff | 70.00 |
| Domain Trusted Cutoff | 70.00 |
| Noise Cutoff | 39.75 |
| Domain Noise Cutoff | 39.75 |
| Isology Type | equivalog_domain |
| HMM Length | 69 |
| Mainrole Category | Regulatory functions |
| Subrole Category | DNA interactions |
| Gene Ontology Term | GO:0003700: sequence-specific DNA binding transcription factor activity molecular_function |
| | GO:0006355: regulation of transcription, DNA-dependent biological_process |
| | GO:0006768: biotin metabolic process biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents the amino-terminal helix-turn-helix repressor region of the biotin--acetyl-CoA-carboxylase ligase/biotin operon repressor bifunctional protein BirA. In many species, the biotin--acetyl-CoA-carboxylase ligase ortholog lacks this DNA-binding repressor region and therefore is not equivalent to the well-characterized BirA of E. coli.
This HMM may recognize some other putative repressor proteins, such as DnrO of Streptomyces peucetius with scores below the noise cutoff but with significance shown by low E-value. |
| References | A2 hmmalign
SE TIGR
GA hmmls
AL clustalw, belvu, seaview
BD build_dir/0181 |
| Genome Property | GenProp0036: biotin biosynthesis (HMM) |
