HMM Summary Page: TIGR00122

Functionbiotin operon repressor
Trusted Cutoff70.00
Domain Trusted Cutoff70.00
Noise Cutoff39.75
Domain Noise Cutoff39.75
Isology Typeequivalog_domain
HMM Length69
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0006768: biotin metabolic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the amino-terminal helix-turn-helix repressor region of the biotin--acetyl-CoA-carboxylase ligase/biotin operon repressor bifunctional protein BirA. In many species, the biotin--acetyl-CoA-carboxylase ligase ortholog lacks this DNA-binding repressor region and therefore is not equivalent to the well-characterized BirA of E. coli. This HMM may recognize some other putative repressor proteins, such as DnrO of Streptomyces peucetius with scores below the noise cutoff but with significance shown by low E-value.
ReferencesA2 hmmalign SE TIGR GA hmmls AL clustalw, belvu, seaview BD build_dir/0181
Genome PropertyGenProp0036: biotin biosynthesis (HMM)