HMM Summary Page: TIGR00121

Functionbiotin--[acetyl-CoA-carboxylase] ligase
Trusted Cutoff83.10
Domain Trusted Cutoff83.10
Noise Cutoff76.45
Domain Noise Cutoff76.45
Isology Typeequivalog_domain
EC Number6.3.4.15
HMM Length235
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0004077: biotin-[acetyl-CoA-carboxylase] ligase activity molecular_function
GO:0006464: protein modification process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the biotin--acetyl-CoA-carboxylase ligase region of biotin--acetyl-CoA-carboxylase ligase. In Escherichia coli and some other species, this enzyme is part of a bifunction protein BirA that includes a small, N-terminal biotin operon repressor domain. Proteins identified by this model should not be called bifunctional unless they are also identified by birA_repr_reg (TIGR00122). The protein name suggests that this enzyme transfers biotin only to acetyl-CoA-carboxylase but it also transfers the biotin moiety to other proteins. The apparent orthologs among the eukaryotes are larger proteins that contain a single copy of this domain.
ReferencesRM 3536662 RT DNA-binding and enzymatic domains of the bifunctional biotin operon repressor (BirA) of Escherichia coli. RA Buoncristiani MR, Howard PK, Otsuka AJ RL Gene 1986;44(2-3):255-61 SE TIGR
Genome PropertyGenProp0036: biotin biosynthesis (HMM)