HMM Summary Page: TIGR00115

Functiontrigger factor
Gene Symboltig
Trusted Cutoff180.20
Domain Trusted Cutoff180.20
Noise Cutoff154.50
Domain Noise Cutoff154.50
Isology Typeequivalog
EC Number5.2.1.8
HMM Length410
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
Gene Ontology TermGO:0003755: peptidyl-prolyl cis-trans isomerase activity molecular_function
GO:0005854: nascent polypeptide-associated complex cellular_component
GO:0051082: unfolded protein binding molecular_function
GO:0051083: 'de novo' cotranslational protein folding biological_process
AuthorAnolik RT, Richardson DL, Haft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentTrigger factor is a ribosome-associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. Trigger factor can bind at the same time as the signal recognition particle (SRP), but is excluded by the SRP receptor (FtsY). The central domain of trigger factor has peptidyl-prolyl cis/trans isomerase activity. This protein is found in a single copy in virtually every bacterial genome.
ReferencesRN [1] RM PMID:15837180 RT A cradle for new proteins: trigger factor at the ribosome. RA Maier T, Ferbitz L, Deuerling E, Ban N RL Curr Opin Struct Biol. 2005 Apr;15(2):204-12. RN [2] RM PMID:15175291 RT Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains. RA Kramer G, Rutkowska A, Wegrzyn RD, Patzelt H, Kurz TA, Merz F, Rauch T, Vorderwulbecke S, Deuerling E, Bukau B RL J Bacteriol. 2004 Jun;186(12):3777-84. DR PROSITE; PS00453; FKBP_PPIASE_1 DR PROSITE; PS00454; FKBP_PPIASE_2 DR PROSITE; PS50059; FKBP_PPIASE_3 DR PROSITE; PDOC00426 SE TIGR DR HAMAP; MF_00303; 489 of 514
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)