| Accession | TIGR00114 |
| Name | lumazine-synth |
| Function | 6,7-dimethyl-8-ribityllumazine synthase |
| Gene Symbol | ribH |
| Trusted Cutoff | 84.60 |
| Domain Trusted Cutoff | 84.60 |
| Noise Cutoff | 77.65 |
| Domain Noise Cutoff | 77.65 |
| Isology Type | equivalog |
| EC Number | 2.5.1.78 |
| HMM Length | 138 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Riboflavin, FMN, and FAD |
| Gene Ontology Term | GO:0000906: 6,7-dimethyl-8-ribityllumazine synthase activity molecular_function |
| | GO:0009231: riboflavin biosynthetic process biological_process |
| | GO:0009349: riboflavin synthase complex cellular_component |
| Author | Anolik RT, Richardson DL, Selengut J |
| Entry Date | Apr 20 1999 2:09PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme catalyzes the cyclo-ligation of 3,4-dihydroxy-2-butanone-4-P and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 6,7-dimethyl-8-ribityllumazine, the immediate precursor of riboflavin. Sometimes referred to as riboflavin synthase, beta subunit, this should not be confused with the alpha subunit which carries out the subsequent reaction.
Archaeal members of this family are considered putative, although included in the seed and scoring above the trusted cutoff. |
| References | DR ECOCYC; EG11322; RIBH.
DR PF00885; DMRL_synthase HMM;
SE TIGR
GA hmmls
AL clustalw
RM 96007536
DR HAMAP; MF_00178; 387 of 402 |
| Genome Property | GenProp0112: riboflavin, FAD and FMN from GTP and ribulose-5-P (HMM) |
