HMM Summary Page: TIGR00112

Functionpyrroline-5-carboxylate reductase
Gene SymbolproC
Trusted Cutoff196.75
Domain Trusted Cutoff196.75
Noise Cutoff89.05
Domain Noise Cutoff89.05
Isology Typeequivalog
EC Number1.5.1.2
HMM Length263
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryGlutamate family
Gene Ontology TermGO:0004735: pyrroline-5-carboxylate reductase activity molecular_function
GO:0006561: proline biosynthetic process biological_process
AuthorHaft DH, Anolik RT, Richardson DL
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs.
ReferencesA2 hmmalign DR PROSITE; PDOC00451 SE TIGR GA hmmls RM 11418582 RT Multiple genes for the last step of proline biosynthesis in Bacillus subtilis. RA Belitsky BR, Brill J, Bremer E, Sonenshein AL. RL J Bacteriol 2001 Jul;183(14):4389-92
Genome PropertyGenProp0111: proline biosynthesis from glutamate (HMM)