| Accession | TIGR00112 |
| Name | proC |
| Function | pyrroline-5-carboxylate reductase |
| Gene Symbol | proC |
| Trusted Cutoff | 196.75 |
| Domain Trusted Cutoff | 196.75 |
| Noise Cutoff | 89.05 |
| Domain Noise Cutoff | 89.05 |
| Isology Type | equivalog |
| EC Number | 1.5.1.2 |
| HMM Length | 263 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Glutamate family |
| Gene Ontology Term | GO:0004735: pyrroline-5-carboxylate reductase activity molecular_function |
| | GO:0006561: proline biosynthetic process biological_process |
| Author | Haft DH, Anolik RT, Richardson DL |
| Entry Date | Apr 20 1999 2:09PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme catalyzes the final step in proline biosynthesis. Among the four paralogs in Bacillus subtilis (proG, proH, proI, and comER), ComER is the most divergent and does not prevent proline auxotrophy from mutation of the other three. It is excluded from the seed and scores between the trusted and noise cutoffs. |
| References | A2 hmmalign
DR PROSITE; PDOC00451
SE TIGR
GA hmmls
RM 11418582
RT Multiple genes for the last step of proline biosynthesis in Bacillus subtilis.
RA Belitsky BR, Brill J, Bremer E, Sonenshein AL.
RL J Bacteriol 2001 Jul;183(14):4389-92 |
| Genome Property | GenProp0111: proline biosynthesis from glutamate (HMM) |
