HMM Summary Page: TIGR00111

FunctionmRNA surveillance protein pelota
Trusted Cutoff177.65
Domain Trusted Cutoff177.65
Noise Cutoff128.20
Domain Noise Cutoff128.20
Isology Typeequivalog
HMM Length351
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
AuthorHaft DH, Anolik RT, Richardson DL
Entry DateApr 20 1999 2:09PM
Last ModifiedDec 8 2011 4:29PM
CommentThis model describes the Drosophila protein Pelota, the budding yeast protein DOM34 which it can replace, and a set of closely related archaeal proteins. Members contain a proposed RNA binding motif. The meiotic defect in pelota mutants may be a complex result of a protein translation defect, as suggested in yeast by ribosomal protein RPS30A being a multicopy suppressor and by an altered polyribosome profile in DOM34 mutants rescued by RPS30A. This family is homologous to a family of peptide chain release factors. Pelota is proposed to act in protein translation.
ReferencesDR SGD; L0000517; FLYBASE; FBgn0011207; RN [1] RM PMID:20876129 RT Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1alpha complex. RA Kobayashi K, Kikuno I, Kuroha K, Saito K, Ito K, Ishitani R, Inada T, Nureki O RL Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17575-9. RN [2] RM PMID: 7588080 RT The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis. RA Eberhart CG, Wasserman SA. RL Development 1995 Oct;121(10):3477-86 RN [3] RM 8900058 RT An archaebacterial homolog of pelota, a meiotic cell division protein in eukaryotes. RA Ragan MA, Logsdon JM Jr, Sensen CW, Charlebois RL, Doolittle WF. RL FEMS Microbiol Lett 1996 Nov 1;144(2-3):151-5 RN [4] RM 9584085 RT Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes. RA Davis L, Engebrecht J. RL Genetics 1998 May;149(1):45-56 RN [5] RM 7518079 RT A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme? RL Nucleic Acids Res 1994 Jun 11;22(11):2166-7 RA Koonin EV, Bork P, Sander C.