HMM Summary Page: TIGR00110

Functiondihydroxy-acid dehydratase
Gene SymbolilvD
Trusted Cutoff618.15
Domain Trusted Cutoff618.15
Noise Cutoff339.10
Domain Noise Cutoff339.10
Isology Typeequivalog
EC Number4.2.1.9
HMM Length543
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0004160: dihydroxy-acid dehydratase activity molecular_function
GO:0009097: isoleucine biosynthetic process biological_process
GO:0009099: valine biosynthetic process biological_process
AuthorAnolik RT, Richardson DL, Haft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein, dihydroxy-acid dehydratase, catalyzes the fourth step in valine and isoleucine biosynthesis. It contains a catalytically essential [4Fe-4S] cluster This model generates scores of up to 150 bits vs. 6-phosphogluconate dehydratase, a homologous enzyme.
ReferencesDR PROSITE: PDOC00690 SE TIGR GA hmmls DR HAMAP; MF_00012; 409 of 418
Genome PropertyGenProp0162: isoleucine biosynthesis from threonine and pyruvate (HMM)
GenProp0163: valine biosynthesis from pyruvate (HMM)
GenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)