HMM Summary Page: TIGR00100

Functionhydrogenase nickel insertion protein HypA
Gene SymbolhypA
Trusted Cutoff88.10
Domain Trusted Cutoff88.10
Noise Cutoff56.80
Domain Noise Cutoff56.80
Isology Typeequivalog
HMM Length116
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0006464: protein modification process biological_process
GO:0008901: ferredoxin hydrogenase activity molecular_function
AuthorHaft DH, Anolik RT
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentCXXC-~12X-CXXC and genetically seems a regulatory protein. In Hpylori, hypA mutant abolished hydrogenase activity and decrease in urease activity. Nickel supplementation in media restored urease activity and partial hydrogenase activity. HypA probably involved in inserting Ni in enzymes.
ReferencesSE TIGR RM 12081959 RT Network of hydrogenase maturation in Escherichia coli: role of accessory proteins HypA and HybF. RA Hube M, Blokesch M, Bock A. RL J Bacteriol 2002 Jul;184(14):3879-85 DR HAMAP; MF_00213; 97 of 111