HMM Summary Page: TIGR00097

Functionhydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase
Gene SymbolthiD
Trusted Cutoff204.95
Domain Trusted Cutoff204.95
Noise Cutoff79.35
Domain Noise Cutoff79.35
Isology Typeequivalog_domain
EC Number2.7.1.49
HMM Length254
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0008972: phosphomethylpyrimidine kinase activity molecular_function
GO:0009228: thiamine biosynthetic process biological_process
AuthorHaft DH, Richardson DL, Anolik RT
Entry DateApr 20 1999 2:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a bifunctional enzyme, phosphomethylpyrimidine kinase (EC kinase (EC, the ThiD/J protein of thiamine biosynthesis. The protein is commonly observed within operons containing other thiamine biosynthesis genes. Numerous examples are fusion proteins with other thiamine-biosynthetic domains. Saccaromyces has three recent paralogs, two of which are isofunctional and score above the trusted cutoff. The third shows a longer branch length in a phylogenetic tree and scores below the trusted cutoff, as do putative second copies in a number of species.
ReferencesRN [1] RM PMID:10075431 RT Cloning and characterization of the thiD/J gene of Escherichia coli encoding a thiamin-synthesizing bifunctional enzyme, hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase. RA Mizote T, Tsuda M, Smith DD, Nakayama H, Nakazawa T RL Microbiology. 1999 Feb;145 ( Pt 2):495-501.
Genome PropertyGenProp0253: thiamine: hydroxymethylpyrimidine pyrophosphate from aminoimidazole ribotide (HMM)