HMM Summary Page: TIGR00095

Function16S rRNA (guanine(966)-N(2))-methyltransferase RsmD
Gene SymbolrsmD
Trusted Cutoff117.50
Domain Trusted Cutoff117.50
Noise Cutoff67.90
Domain Noise Cutoff67.90
Isology Typeequivalog
EC Number2.1.1.171
HMM Length194
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0008168: methyltransferase activity molecular_function
GO:0031167: rRNA methylation biological_process
AuthorRichardson DL, Anolik RT, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a family of uncharacterized bacterial proteins. Members are present in nearly every complete bacterial genome, always in a single copy. PSI-BLAST analysis shows homology to several families of SAM-dependent methyltransferases, including ribosomal RNA adenine dimethylases.
ReferencesRN [1] RM PMID:17189261 RT Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. RA Lesnyak DV, Osipiuk J, Skarina T, Sergiev PV, Bogdanov AA, Edwards A, Savchenko A, Joachimiak A, Dontsova OA RL J Biol Chem. 2007 Feb 23;282(8):5880-7. RN [2] RM PMID:22535590 RT Properties of small rRNA methyltransferase RsmD: mutational and kinetic study. RA Sergeeva OV, Prokhorova IV, Ordabaev Y, Tsvetkov PO, Sergiev PV, Bogdanov AA, Makarov AA, Dontsova OA RL RNA. 2012 Jun;18(6):1178-85. doi: 10.1261/rna.032763.112.