HMM Summary Page: TIGR00090

Functionribosome silencing factor
Gene SymbolrsfS
Trusted Cutoff56.90
Domain Trusted Cutoff56.90
Noise Cutoff52.95
Domain Noise Cutoff52.95
Isology Typeequivalog
HMM Length99
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0008150: biological_process biological_process
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedAug 30 2012 10:18AM
CommentThis model describes a widely distributed family of bacterial proteins related to iojap from plants. It includes RsfS(YbeB) from E. coli. The gene iojap is a pattern-striping gene in maize, reflecting a chloroplast development defect in some cells. The conserved function of this protein is to silence ribosomes by binding the ribosomal large subunit and impairing joining with the small subunit in response to nutrient stress. Note that RsfS (starvation) is an author-endorsed change from the published symbol RsfA, which conflicted with previously published gene symbols.
ReferencesAL msa RN [1] RM PMID:22829778 RT RsfA (YbeB) Proteins Are Conserved Ribosomal Silencing Factors. RA Hauser R, Pech M, Kijek J, Yamamoto H, Titz B, Naeve F, Tovchigrechko A, Yamamoto K, Szaflarski W, Takeuchi N, Stellberger T, Diefenbacher ME, Nierhaus KH, Uetz P RL PLoS Genet. 2012 Jul;8(7):e1002815. Epub 2012 Jul 19. RN [2] RM PMID:22238375 RT C7orf30 specifically associates with the large subunit of the mitochondrial ribosome and is involved in translation. RA Wanschers BF, Szklarczyk R, Pajak A, van den Brand MA, Gloerich J, Rodenburg RJ, Lightowlers RN, Nijtmans LG, Huynen MA RL Nucleic Acids Res. 2012 May;40(9):4040-51. Epub 2012 Jan 11. RN [3] RM PMID:17337586 RT Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques. RA Jiang M, Sullivan SM, Walker AK, Strahler JR, Andrews PC, Maddock JR RL J Bacteriol. 2007 May;189(9):3434-44. RN [4] RM 98283854 RT Mapping of promoters for the nucleus-encoded plastid RNA polymerase (NEP) in the iojap maize mutant. RA Silhavy D, Maliga P RL Curr Genet 1998 May;33(5):340-4