HMM Summary Page: TIGR00087

Function5'/3'-nucleotidase SurE
Gene SymbolsurE
Trusted Cutoff135.10
Domain Trusted Cutoff135.10
Noise Cutoff33.20
Domain Noise Cutoff33.20
Isology Typeequivalog
EC Number3.1.3.5
HMM Length252
Mainrole CategoryCellular processes
Subrole CategoryAdaptations to atypical conditions
Gene Ontology TermGO:0006950: response to stress biological_process
GO:0008253: 5'-nucleotidase activity molecular_function
GO:0008254: 3'-nucleotidase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family originally was named SurE because of its role in stationary phase survivalin Escherichia coli. In E. coli, surE is next to pcm, an L-isoaspartyl protein repair methyltransferase that is also required for stationary phase survival. Recent work (PMID:15489502) shows that viewing SurE as an acid phosphatase ( is not accurate. Rather, SurE in E. coli, Thermotoga maritima, and Pyrobaculum aerophilum acts strictly on nucleoside 5'- and 3'-monophosphates. E. coli SurE is Recommended cutoffs are 15 for homology, 40 for probable orthology, and 200 for orthology with full-length homology.
ReferencesRN [1] RM 93046805 RT Complementation of Saccharomyces cerevisiae acid phosphatase mutation by a genomic sequence from the yeast Yarrowia lipolytica identifies a new phosphatase. RA Treton BY, Le Dall MT, Gaillardin CM RL Curr Genet 1992 Nov;22(5):345-55 RN [2] RM 12595266 RT Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. RA Mura C, Katz JE, Clarke SG, Eisenberg D. RL J Mol Biol. 2003 Mar 7;326(5):1559-75. Erratum in: J Mol Biol. 2003 Apr 25;328(2):517. RN [3] RM 11709173 RT Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. RA Zhang RG, Skarina T, Katz JE, Beasley S, Khachatryan A, Vyas S, Arrowsmith CH, Clarke S, Edwards A, Joachimiak A, Savchenko A. RL Structure (Camb). 2001 Nov;9(11):1095-106. RN [4] RM 15489502 RT General enzymatic screens identify three new nucleotidases in Escherichia coli. Biochemical characterization of SurE, YfbR, and YjjG. RA Proudfoot M, Kuznetsova E, Brown G, Rao NN, Kitagawa M, Mori H, Savchenko A, Yakunin AF. RL J Biol Chem. 2004 Dec 24;279(52):54687-94. DR HAMAP; MF_00060; 366 of 372