HMM Summary Page: TIGR00084

FunctionHolliday junction DNA helicase RuvA
Gene SymbolruvA
Trusted Cutoff116.45
Domain Trusted Cutoff116.45
Noise Cutoff81.50
Domain Noise Cutoff81.50
Isology Typeequivalog
EC Number3.6.4.12
HMM Length192
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006310: DNA recombination biological_process
GO:0009378: four-way junction helicase activity molecular_function
GO:0009379: Holliday junction helicase complex cellular_component
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentRuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions.
ReferencesSE TIGR GA hmmls RN [1] RM 98105106 RT Processing of recombination intermediates by the RuvABC proteins. RA West SC RL Annu Rev Genet 1997;31:213-44 RN [2] RM 97199382 DR HAMAP; MF_00031; 463 of 486
Genome PropertyGenProp0198: ruvABC Holliday junction complex (HMM)