HMM Summary Page: TIGR00079

Functionpeptide deformylase
Gene Symboldef
Trusted Cutoff103.95
Domain Trusted Cutoff103.95
Noise Cutoff74.15
Domain Noise Cutoff74.15
Isology Typeequivalog
EC Number3.5.1.88
HMM Length161
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0006464: protein modification process biological_process
GO:0042586: peptide deformylase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentPeptide deformylase (EC, also called polypeptide deformylase, is a metalloenzyme that uses water to release formate from the N-terminal formyl-L-methionine of bacterial and chloroplast peptides. This enzyme should not be confused with formylmethionine deformylase (EC which is active on free N-formyl methionine and has been reported from rat intestine.
ReferencesRM 97272005 RT Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion. RA Meinnel T, Lazennec C, Villoing S, Blanquet S RL J Mol Biol 1997 Apr 4;267(3):749-61 SE TIGR AL clustalw DR HAMAP; MF_00163; 323 of 332