Accession | TIGR00074 |
Name | hypC_hupF |
Function | hydrogenase assembly chaperone HypC/HupF |
Gene Symbol | hypC |
Trusted Cutoff | 48.00 |
Domain Trusted Cutoff | 48.00 |
Noise Cutoff | 39.50 |
Domain Noise Cutoff | 39.50 |
Isology Type | equivalog |
HMM Length | 80 |
Mainrole Category | Protein fate |
Subrole Category | Protein folding and stabilization |
Gene Ontology Term | GO:0006461: protein complex assembly biological_process |
| GO:0016530: metallochaperone activity molecular_function |
| GO:0051082: unfolded protein binding molecular_function |
Author | Haft DH |
Entry Date | Apr 20 1999 2:08PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | See Medline:98153179 for function. This protein is suggested by act as a chaperone for a hydrogenase large subunit, holding the precursor form before metallocenter nickel incorporation.
[SS 12/31/03] More recently proposed additional function is to shuttle the iron atom that has been liganded at the HypC/HypD complex to the precursor of the large hydrogenase (HycE) subunit. PMID:12441107. Added metallochaperone and protein mod GO terms. |
References | A2 hmmalign
SE TIGR
GA hmmsw
AL clustal, edit
BD build_dir/0071
RM 98153179
RT Interaction of the hydrogenase accessory protein HypC with HycE, the large subunit of Escherichia coli hydrogenase 3 during enzyme maturation.
RA Drapal N, Bock A
RL Biochemistry 1998 Mar 3;37(9):2941-8 |
Genome Property | GenProp0177: nickel-dependent hydrogenase (HMM) |