HMM Summary Page: TIGR00074

Functionhydrogenase assembly chaperone HypC/HupF
Gene SymbolhypC
Trusted Cutoff48.00
Domain Trusted Cutoff48.00
Noise Cutoff39.50
Domain Noise Cutoff39.50
Isology Typeequivalog
HMM Length80
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
Gene Ontology TermGO:0006461: protein complex assembly biological_process
GO:0016530: metallochaperone activity molecular_function
GO:0051082: unfolded protein binding molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentSee Medline:98153179 for function. This protein is suggested by act as a chaperone for a hydrogenase large subunit, holding the precursor form before metallocenter nickel incorporation. [SS 12/31/03] More recently proposed additional function is to shuttle the iron atom that has been liganded at the HypC/HypD complex to the precursor of the large hydrogenase (HycE) subunit. PMID:12441107. Added metallochaperone and protein mod GO terms.
ReferencesA2 hmmalign SE TIGR GA hmmsw AL clustal, edit BD build_dir/0071 RM 98153179 RT Interaction of the hydrogenase accessory protein HypC with HycE, the large subunit of Escherichia coli hydrogenase 3 during enzyme maturation. RA Drapal N, Bock A RL Biochemistry 1998 Mar 3;37(9):2941-8
Genome PropertyGenProp0177: nickel-dependent hydrogenase (HMM)