HMM Summary Page: TIGR00073

Functionhydrogenase accessory protein HypB
Gene SymbolhypB
Trusted Cutoff121.20
Domain Trusted Cutoff121.20
Noise Cutoff85.40
Domain Noise Cutoff85.40
Isology Typeequivalog
HMM Length217
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0000166: nucleotide binding molecular_function
GO:0006464: protein modification process biological_process
GO:0016530: metallochaperone activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentA GTP hydrolase for assembly of nickel metallocenter of hydrogenase. A similar protein, ureG, is an accessory protein for urease, which also uses nickel. hits scoring 75 and above are safe as orthologs. [SS 1/05/04 I changed the role_ID and process GO from protein folding to to protein modification, since a protein folding role has not been established, but HypB is implicated in insertion of nickel into the large subunit of NiFe hydrogenases.]
ReferencesA2 hmmalign SE TIGR GA hmmsw AL msa BD build_dir/0070
Genome PropertyGenProp0177: nickel-dependent hydrogenase (HMM)