HMM Summary Page: TIGR00068

Functionlactoylglutathione lyase
Gene SymbolgloA
Trusted Cutoff122.45
Domain Trusted Cutoff122.45
Noise Cutoff61.30
Domain Noise Cutoff61.30
Isology Typeequivalog
EC Number4.4.1.5
HMM Length150
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryAmino sugars
Gene Ontology TermGO:0004462: lactoylglutathione lyase activity molecular_function
GO:0005975: carbohydrate metabolic process biological_process
GO:0051596: methylglyoxal catabolic process biological_process
AuthorRichardson DL
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentLactoylglutathione lyase is also known as aldoketomutase and glyoxalase I. Glyoxylase I is a homodimer in many species. In some eukaryotes, including yeasts and plants, the orthologous protein carries a tandem duplication, is twice as long, and hits this HMM twice.
ReferencesA2 hmmalign DR PROSITE; PDOC00720; SE TIGR GA hmmfs AL msa BD build_dir/0034
Genome PropertyGenProp0744: glyoxalase pathway, glutathione dependent (HMM)