HMM Summary Page: TIGR00063

FunctionGTP cyclohydrolase I
Gene SymbolfolE
Trusted Cutoff181.60
Domain Trusted Cutoff181.60
Noise Cutoff100.90
Domain Noise Cutoff100.90
Isology Typeequivalog
EC Number3.5.4.16
HMM Length180
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryFolic acid
Gene Ontology TermGO:0003934: GTP cyclohydrolase I activity molecular_function
GO:0042559: pteridine-containing compound biosynthetic process biological_process
GO:0046654: tetrahydrofolate biosynthetic process biological_process
AuthorRichardson DL
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
Commentalternate names: Punch (Drosophila), GTP cyclohydrolase I (EC catalyzes the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects.
ReferencesDR PROSITE: PDOC00672; GTP cyclohydrolase I signatures DR COG; 0302; SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00223; 231 of 239
Genome PropertyGenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM)