| Accession | TIGR00063 |
| Name | folE |
| Function | GTP cyclohydrolase I |
| Gene Symbol | folE |
| Trusted Cutoff | 181.60 |
| Domain Trusted Cutoff | 181.60 |
| Noise Cutoff | 100.90 |
| Domain Noise Cutoff | 100.90 |
| Isology Type | equivalog |
| EC Number | 3.5.4.16 |
| HMM Length | 180 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Folic acid |
| Gene Ontology Term | GO:0003934: GTP cyclohydrolase I activity molecular_function |
| | GO:0042559: pteridine-containing compound biosynthetic process biological_process |
| | GO:0046654: tetrahydrofolate biosynthetic process biological_process |
| Author | Richardson DL |
| Entry Date | Apr 20 1999 2:07PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | alternate names: Punch (Drosophila),
GTP cyclohydrolase I (EC 3.5.4.16) catalyzes the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP. This reaction is the first step in the biosynthesis of tetrahydrofolate in prokaryotes, of tetrahydrobiopterin in vertebrates, and of pteridine-containing pigments in insects.
|
| References | DR PROSITE: PDOC00672; GTP cyclohydrolase I signatures
DR COG; 0302;
SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_00223; 231 of 239 |
| Genome Property | GenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM) |
