HMM Summary Page: TIGR00056

FunctionABC transport permease subunit
Trusted Cutoff212.20
Domain Trusted Cutoff212.20
Noise Cutoff101.00
Domain Noise Cutoff101.00
Isology Typesubfamily
HMM Length260
Mainrole CategoryHypothetical proteins
Subrole CategoryConserved
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a subfamily of ABC transporter permease subunits. One member of this family has been associated with the toluene tolerance phenotype of Pseudomonas putida, another with L-glutamate transport, another with maintenance of lipid asymmetry. Many bacterial species have one or two members. The Mycobacteria have large paralogous families included in the DUF140 family but excluded from this subfamily on based on extreme divergence at the amino end and on phylogenetic and UPGMA trees on the more conserved regions.
ReferencesRN [1] RM PMID:16495545 RT Identification of a meningococcal L-glutamate ABC transporter operon essential for growth in low-sodium environments. RA Monaco C, Tala A, Spinosa MR, Progida C, De Nitto E, Gaballo A, Bruni CB, Bucci C, Alifano P RL Infect Immun. 2006 Mar;74(3):1725-40. RN [2] RM PMID:19383799 RT An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. RA Malinverni JC, Silhavy TJ RL Proc Natl Acad Sci U S A. 2009 May 12;106(19):8009-14. DR PFAM; PF02405; DUF140 DR IPR003453; DUF140