HMM Summary Page: TIGR00053

Functionaddiction module toxin component, YafQ family
Trusted Cutoff87.25
Domain Trusted Cutoff87.25
Noise Cutoff52.65
Domain Noise Cutoff52.65
Isology Typesubfamily
HMM Length92
Mainrole CategoryCellular processes
Subrole CategoryAdaptations to atypical conditions
Gene Ontology TermGO:0004519: endonuclease activity molecular_function
GO:0006448: regulation of translational elongation biological_process
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a cluster of eubacterial proteins and a cluster of archaeal proteins, all of which are uncharacterized, from 85 to 102 residues in length, and similar in sequence. These include YafQ, a ribosome-associated endoribonuclease that serves as part of a toxin-antitoxin system, for which DinJ is the antidote component.
ReferencesRN [1] RM PMID:19210620 RT Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. RA Prysak MH, Mozdzierz CJ, Cook AM, Zhu L, Zhang Y, Inouye M, Woychik NA RL Mol Microbiol. 2009 Mar;71(5):1071-87.
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)