| Accession | TIGR00053 |
| Name | TIGR00053 |
| Function | addiction module toxin component, YafQ family |
| Trusted Cutoff | 87.25 |
| Domain Trusted Cutoff | 87.25 |
| Noise Cutoff | 52.65 |
| Domain Noise Cutoff | 52.65 |
| Isology Type | subfamily |
| HMM Length | 92 |
| Mainrole Category | Cellular processes |
| Subrole Category | Adaptations to atypical conditions |
| Gene Ontology Term | GO:0004519: endonuclease activity molecular_function |
| | GO:0006448: regulation of translational elongation biological_process |
| Author | Richardson DL, Haft DH |
| Entry Date | Apr 20 1999 2:04PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents a cluster of eubacterial proteins and a cluster of archaeal proteins, all of which are uncharacterized, from 85 to 102 residues in length, and similar in sequence. These include YafQ, a ribosome-associated endoribonuclease that serves as part of a toxin-antitoxin system, for which DinJ is the antidote component. |
| References | RN [1]
RM PMID:19210620
RT Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage.
RA Prysak MH, Mozdzierz CJ, Cook AM, Zhu L, Zhang Y, Inouye M, Woychik NA
RL Mol Microbiol. 2009 Mar;71(5):1071-87. |
| Genome Property | GenProp0321: toxin-antitoxin system, type II (HMM) |
