HMM Summary Page: TIGR00052

Functionnudix-type nucleoside diphosphatase, YffH/AdpP family
Trusted Cutoff79.55
Domain Trusted Cutoff79.55
Noise Cutoff64.10
Domain Noise Cutoff64.10
Isology Typesubfamily
EC Number3.6.1.-
HMM Length188
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0016462: pyrophosphatase activity molecular_function
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedAug 12 2012 7:01PM
CommentMembers of this family include proteins of about 200 amino acids, including the recently characterized nudix hydrolase YffH, shows to be highly active as a GDP-mannose pyrophosphatase. It also includes the C-terminal half of a 361-amino acid protein, TrgB from Rhodobacter sphaeroides, shown experimentally to help confer tellurite resistance. This HMM also hits a region near the C-terminus of a 1092-amino acid protein of C. elegans.
ReferencesSE TIGR AL msa RN [1] RM PMID: 16766526 RT Three New Nudix Hydrolases from Escherichia coli. RA Xu W, Dunn CA, O'handley SF, Smith DL, Bessman MJ RL J Biol Chem. 2006 Aug 11;281(32):22794-8.