HMM Summary Page: TIGR00043

FunctionrRNA maturation RNase YbeY
Gene SymbolybeY
Trusted Cutoff42.05
Domain Trusted Cutoff42.05
Noise Cutoff38.05
Domain Noise Cutoff38.05
Isology Typeequivalog
HMM Length111
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0008150: biological_process biological_process
GO:0046872: metal ion binding molecular_function
AuthorRichardson DL, Haft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedMay 22 2014 4:32PM
CommentThis metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect.
ReferencesDR HAMAP; MF_00009; 511 of 518 RN [1] RM PMID:23273979 RT Conserved bacterial RNase YbeY plays key roles in 70S ribosome quality control and 16S rRNA maturation. RA Jacob AI, Kohrer C, Davies BW, RajBhandary UL, Walker GC RL Mol Cell. 2013 Feb 7;49(3):427-38. doi: 10.1016/j.molcel.2012.11.025. RN [2] RM PMID:20807199 RT Role of Escherichia coli YbeY, a highly conserved protein, in rRNA processing. RA Davies BW, Kohrer C, Jacob AI, Simmons LA, Zhu J, Aleman LM, Rajbhandary UL, Walker GC RL Mol Microbiol. 2010 Oct;78(2):506-18. RN [3] RM PMID:16511207 RT The ybeY protein from Escherichia coli is a metalloprotein. RA Zhan C, Fedorov EV, Shi W, Ramagopal UA, Thirumuruhan R, Manjasetty BA, Almo SC, Fiser A, Chance MR, Fedorov AA RL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt 11):959-63. Epub 2005 Oct 20.
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)