HMM Summary Page: TIGR00042

Functionnon-canonical purine NTP pyrophosphatase, RdgB/HAM1 family
Gene SymbolrdgB
Trusted Cutoff145.35
Domain Trusted Cutoff145.35
Noise Cutoff55.90
Domain Noise Cutoff55.90
Isology Typeequivalog
EC Number3.6.1.-
HMM Length184
Mainrole CategoryDNA metabolism
Subrole CategoryDNA replication, recombination, and repair
Gene Ontology TermGO:0006281: DNA repair biological_process
GO:0016462: pyrophosphatase activity molecular_function
AuthorHaft DH, Richardson DL, Anolik RT
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 28 2011 3:53PM
CommentSaccharomyces cerevisiae HAM1 protects against the mutagenic effects of the base analog 6-N-hydroxylaminopurine, which can be a natural product of monooxygenase activity on adenine. Methanococcus jannaschii MJ0226 and E. coli RdgB are also characterized as pyrophosphatases active against non-standard purines NTPs. E. coli RdgB appears to act by intercepting non-canonical deoxyribonucleotide triphosphates from replication precursor pools.[3]
ReferencesSE TIGR GA hmmsw AL clustalw DR URL;; RN [1] RM 87031562 RT Mutants of Saccharomyces cerevisiae supersensitive to the mutagenic effect of 6-N-hydroxylaminopurine. RA Pavlov IuI RL Genetika 22, 2235-43 (1986). RN [2] RM 96381244 RT HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae. RA Noskov VN, Staak K, Shcherbakova PV, Kozmin SG, Negishi K, Ono BC, Hayatsu H, Pavlov YI RL Yeast 1996 Jan;12(1):17-29 RN [3] RM 12730170 RT Repair system for noncanonical purines in Escherichia coli. RA Burgis NE, Brucker JJ, Cunningham RP RL J Bacteriol. 2003 May;185(10):3101-10 DR HAMAP; MF_01405; 177 of 196