| Accession | TIGR00042 |
| Name | TIGR00042 |
| Function | non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family |
| Gene Symbol | rdgB |
| Trusted Cutoff | 145.35 |
| Domain Trusted Cutoff | 145.35 |
| Noise Cutoff | 55.90 |
| Domain Noise Cutoff | 55.90 |
| Isology Type | equivalog |
| EC Number | 3.6.1.- |
| HMM Length | 184 |
| Mainrole Category | DNA metabolism |
| Subrole Category | DNA replication, recombination, and repair |
| Gene Ontology Term | GO:0006281: DNA repair biological_process |
| | GO:0016462: pyrophosphatase activity molecular_function |
| Author | Haft DH, Richardson DL, Anolik RT |
| Entry Date | Apr 20 1999 2:04PM |
| Last Modified | Feb 28 2011 3:53PM |
| Comment | Saccharomyces cerevisiae HAM1 protects against the mutagenic effects of the base analog 6-N-hydroxylaminopurine, which can be a natural product of monooxygenase activity on adenine. Methanococcus jannaschii MJ0226 and E. coli RdgB are also characterized as pyrophosphatases active against non-standard purines NTPs. E. coli RdgB appears to act by intercepting non-canonical deoxyribonucleotide triphosphates from replication precursor pools.[3] |
| References | SE TIGR
GA hmmsw
AL clustalw
DR URL; http://www.proteome.com/YPD/HAM1.html;
RN [1]
RM 87031562
RT Mutants of Saccharomyces cerevisiae supersensitive to the mutagenic effect of 6-N-hydroxylaminopurine.
RA Pavlov IuI
RL Genetika 22, 2235-43 (1986).
RN [2]
RM 96381244
RT HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae.
RA Noskov VN, Staak K, Shcherbakova PV, Kozmin SG, Negishi K, Ono BC, Hayatsu H, Pavlov YI
RL Yeast 1996 Jan;12(1):17-29
RN [3]
RM 12730170
RT Repair system for noncanonical purines in Escherichia coli.
RA Burgis NE, Brucker JJ, Cunningham RP
RL J Bacteriol. 2003 May;185(10):3101-10
DR HAMAP; MF_01405; 177 of 196 |
