HMM Summary Page: TIGR00040

Functionphosphodiesterase, MJ0936 family
Trusted Cutoff56.25
Domain Trusted Cutoff56.25
Noise Cutoff40.05
Domain Noise Cutoff40.05
Isology Typesubfamily
EC Number3.1.-.-
HMM Length158
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0016788: hydrolase activity, acting on ester bonds molecular_function
AuthorHaft DH, Richardson DL
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this largely uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11, and a family of uncharacterized archaeal putative phosphoesterases described by TIGR00024. In this family, the His residue in GNHD portion of the motif is not conserved. The member MJ0936, one of two from Methanococcus jannaschii, was shown (PMID:15128743) to act on model phosphodiesterase substrates; a divalent cation was required.
ReferencesDR PROSITE; PDOC00976; SE TIGR RM 15128743 RT Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii. RA Chen S, Yakunin AF, Kuznetsova E, Busso D, Pufan R, Proudfoot M, Kim R, Kim SH. RL J Biol Chem. 2004 May 5 [Epub ahead of print]