HMM Summary Page: TIGR00039

Function6-pyruvoyl tetrahydropterin synthase/QueD family protein
Trusted Cutoff125.50
Domain Trusted Cutoff125.50
Noise Cutoff57.25
Domain Noise Cutoff57.25
Isology Typesubfamily
HMM Length124
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0003824: catalytic activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:03PM
Last ModifiedFeb 15 2012 1:49PM
CommentThis model has been downgraded from hypothetical_equivalog to subfamily. The animal enzymes are known to be 6-pyruvoyl tetrahydropterin synthase. The function of the bacterial branch of the sequence lineage had been thought to be the same, but many are now taken to be QueD, and enzyme of queuosine biosynthesis. Queuosine is a hypermodified base in the wobble position of some tRNAs in most species. A new model is built to be the QueD equivalog model.
ReferencesRN [1] RM PMID: 14660578 RT Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. RA Reader JS, Metzgar D, Schimmel P, de Crecy-Lagard V RL J Biol Chem. 2004 Feb 20;279(8):6280-5.