HMM Summary Page: TIGR00028

Functiontoxin-antitoxin system PIN domain toxin
Trusted Cutoff73.60
Domain Trusted Cutoff73.60
Noise Cutoff73.45
Domain Noise Cutoff73.45
Isology Typesubfamily
HMM Length143
AuthorHaft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein consist almost entirely of a PIN (PilT N terminus) domain (see Pfam PF01850). This family was originally defined a set of twelve closely related paralogs found in Mycobacterium tuberculosis, but additional members are found now Synechococcus sp. WH8102, etc. Inspection of genomic regions suggests these represent toxin components of toxin-antitoxin regions, potentially important to creating dormant persister cells.
ReferencesDR PFAM; PF01850; PIN domain